Darren Hargrave is a full professor of Paediatric Neuro-oncology at University College London and Honorary Consultant Paediatric Oncologist at Great Ormond Street Hospital, London UK where he leads the Neuro-oncology and Experimental Therapeutics programme since 2011. Prior to this following training in UK and Canada he was appointed in 2002 as Consultant Paediatric Oncologist where he developed the South Thames Paediatric Neuro-oncology and Drug Development programmes. He has been the Chief Investigator of over 20 Clinical Trials from “first in child” to large Randomised International Phase III studies. He co-leads the newly established UK National NIHR NIHR Brain Tumour Research Consortium. Having previously Chaired the UK NCRI Children’s Cancer Group, European SIOPe Paediatric Brain Tumour Group and was Vice-Chair of the Paediatric Experimental Cancer Medicine Network. He serves on multiple National and International Childhood Cancer organisations including UK NCRI, CRUK and ITCC committees. He has acted as an external scientific advisor/ reviewer for the US Pediatric Brain Tumor Consortium (PBTC), NIH and the French Cancer Agency. He is the Co-chair with Maryam Fouladi of the Collaborative Network of Neuro-Oncology Clinical Trials (CONNECT), an international consortium of 18 leading academic paediatric neuro-oncology centres. He has extensive experience in translational research, development and coordination of clinical trials and leadership of clinical research teams and networks. He has been the Paediatric Oncologist associated with the NHS Complex Neurofibromatosis Type-1 Service for over 15 years and recently joined the EU PEARL Consortium to develop novel therapies for children with NF1 associated tumours.